Human innate immunity

Group leader : Nicolas Manel

New publications from the Manel lab

Lahaye ... Manel. Nuclear envelope protein SUN2 promotes Cyclophilin-A-dependent steps of HIV replication Cell Reports 2016.

Raab, Gentili ... Manel, Piel. ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death. Science 2016.



Postdoctoral position in innate immunity

Applications are currently being accepted for a postdoctoral position in the Human Innate Immunity lab at the Institut Curie, Paris, France. The Human Innate Immunity Lab is interested in understanding the mechanisms that contribute to the activation or evasion of innate immune responses. We use the human immunodeficiency viruses (HIV-1 and HIV-2) and the cytosolic DNA sensor cGAS as models to study immune responses in mammalian immune cells.

Qualifications: Candidates should hold a PhD degree or equivalent and have a strong background in molecular and cellular virology and/or immunology. Applicants should send their resume and the name and contact details of two references to Nicolas Manel ( 

 Our lab is interested in understanding the principles of innate immunity in humans and how it can shape adaptive immunity. Innate immune responses are considered the first line of defense against harmful conditions, including viral infections and cancer. In the immune system, human dendritic cells play a key role in the control of these responses and are a promising component of rational immune therapies. Indeed, dendritic cells couple innate and adaptive responses: they have the ability to detect and sense injured tissues, cellular fragments and pathogens and they associate this sensing with the activation of adaptive T lymphocytes.

Our lab studies HIV, an important human pathogen that causes AIDS, as a model to understand the regulation of innate immunity in human dendritic cells. Human dendritic cells do not normally sense HIV-1. This lack of sensing is linked to the inability of HIV-1 to efficiently replicate in dendritic cells. Indeed, and counter-intuitively, artificially increasing HIV-1 infection in dendritic cells leads to an innate immune response against the virus. This shows that the human immune system is equipped with a cryptic sensor for HIV-1 replication, but HIV-1 evades it. Projects in the lab aim at understanding how this sensing mechanism operates and whether it could be engaged therapeutically or in vaccines. Some of the projects developed in the lab include the study of viral determinants of sensing in HIV, of the cellular mechanisms of sensing and of the impact of the innate sensing and dendritic cells on adaptive immunity. To achieve these aims, we utilize a number of molecular and cellular approaches in the context of immunology and virology, including RNAi, screens, imaging and gene expression analysis.